2104.09182
CELLULAR TANGO: HOW EXTRACELLULAR MATRIX ADHESION CHOREOGRAPHS RAC-RHO SIGNALING AND CELL MOVEMENT
Elisabeth G. Rens, Leah Edelstein-Keshet
incompletemedium confidence
- Category
- Not specified
- Journal tier
- Strong Field
- Processed
- Sep 28, 2025, 12:56 AM
- arXiv Links
- Abstract ↗PDF ↗
Audit review
The paper establishes its claims largely by simulations and qualitative reasoning (e.g., smaller oscillatory regime under catch–slip; frequency increases with ECM-to-Rho feedback) without a rigorous bifurcation analysis, while the model’s solution outlines a plausible center-manifold/normal-form program but leaves key nondegeneracy checks, coefficient computations, and global set-inclusion claims unproven. Hence, both are incomplete, though broadly consistent.
Referee report (LaTeX)
\textbf{Recommendation:} major revisions
\textbf{Journal Tier:} strong field
\textbf{Justification:}
Compelling computational study linking adhesion physics to Rac–Rho patterning, with clear and reproducible model formulations. However, the manuscript lacks analytical support for key claims (onset mode, nature of bifurcations, frequency sensitivities). Incorporating even a minimal linear stability and normal-form analysis (in 1D) would substantially strengthen correctness and interpretability.