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2009.02620

Bayesian information-theoretic calibration of patient-specific radiotherapy sensitivity parameters for informing effective scanning protocols in cancer

Heyrim Cho, Allison L. Lewis, Kathleen M. Storey

correctmedium confidence
Category
math.DS
Journal tier
Specialist/Solid
Processed
Sep 28, 2025, 12:55 AM

Audit review

The paper defines the score Sk(i,r) and empirically demonstrates that larger k shifts selections earlier, recommends day-1 then day-6 under weekly constraints for low radiosensitivity, and shows necrotic metrics are often preferred in the two-compartment setting; these are all consistent with the candidate’s algebraic analysis and policy conclusions. The candidate adds a clean pairwise threshold derivation and a monotonicity proof that the paper does not provide, but which follows directly from the paper’s Equation (9) and observed behavior in figures and summaries. Weekly day-1/day-6 and necrotic-vs-tumor recommendations also align with the paper’s scenarios and conclusions. See the score definition and usage, the weekly guidance, the k–radiosensitivity recommendations, and the two-compartment metric findings .

Referee report (LaTeX)

\textbf{Recommendation:} minor revisions

\textbf{Journal Tier:} specialist/solid

\textbf{Justification:}

The study offers a well-structured MI-based selection framework and delivers actionable guidance across radiosensitivity regimes and scan budgets. Results are consistent and plausible, with thoughtful scenarios including weekly constraints and two-compartment metric selection. A short theoretical section establishing the monotonicity of selections with respect to k and clarifying edge cases would materially enhance rigor without altering conclusions.