2009.02620
Bayesian information-theoretic calibration of patient-specific radiotherapy sensitivity parameters for informing effective scanning protocols in cancer
Heyrim Cho, Allison L. Lewis, Kathleen M. Storey
correctmedium confidence
- Category
- math.DS
- Journal tier
- Specialist/Solid
- Processed
- Sep 28, 2025, 12:55 AM
- arXiv Links
- Abstract ↗PDF ↗
Audit review
The paper defines the score Sk(i,r) and empirically demonstrates that larger k shifts selections earlier, recommends day-1 then day-6 under weekly constraints for low radiosensitivity, and shows necrotic metrics are often preferred in the two-compartment setting; these are all consistent with the candidate’s algebraic analysis and policy conclusions. The candidate adds a clean pairwise threshold derivation and a monotonicity proof that the paper does not provide, but which follows directly from the paper’s Equation (9) and observed behavior in figures and summaries. Weekly day-1/day-6 and necrotic-vs-tumor recommendations also align with the paper’s scenarios and conclusions. See the score definition and usage, the weekly guidance, the k–radiosensitivity recommendations, and the two-compartment metric findings .
Referee report (LaTeX)
\textbf{Recommendation:} minor revisions
\textbf{Journal Tier:} specialist/solid
\textbf{Justification:}
The study offers a well-structured MI-based selection framework and delivers actionable guidance across radiosensitivity regimes and scan budgets. Results are consistent and plausible, with thoughtful scenarios including weekly constraints and two-compartment metric selection. A short theoretical section establishing the monotonicity of selections with respect to k and clarifying edge cases would materially enhance rigor without altering conclusions.