2006.06100
Models for plasma kinetics during simultaneous therapeutic plasma exchange and extracorporeal membrane oxygenation
Charles Puelz, Zach Danial, Jon Marinaro, Jay Raval, Boyce E. Griffith, Charles S. Peskin
correctmedium confidence
- Category
- Not specified
- Journal tier
- Specialist/Solid
- Processed
- Sep 28, 2025, 12:55 AM
- arXiv Links
- Abstract ↗PDF ↗
Audit review
The paper derives the VA/VV DDE models (eqs. (4), (7)) and ADEs (eqs. (5), (8)), gives the switched-port formulas (eqs. (9)–(12)), and shows ADEs are forward-Euler discretizations of the DDEs (Remark 2) with transit-time steps; it also presents the single-compartment reduction and efficiency comparison (Remark 1, eqs. (13)–(16)). The candidate solution reconstructs each of these steps, including the recirculation term αQQ1/(Q1+αQ) + α^2Q^2/(Q1+αQ)·γ2(t−s3), the Euler-to-ADE step, and the s3=0 α-independence in VV-typical, matching the paper’s equations and logic throughout .
Referee report (LaTeX)
\textbf{Recommendation:} minor revisions
\textbf{Journal Tier:} specialist/solid
\textbf{Justification:}
The work is sound and clearly presented, deriving DDE and ADE models for ECMO+TPE (typical and switched). It adds useful insights on discretization (ADE as forward Euler) and reproduces known single-compartment behavior. Numerical comparisons and sensitivity analysis are appropriate. Minor clarifications on initial histories and explicit statement of modeling assumptions would further strengthen the presentation.